680576-44-7

Usage

Structure

1H-Isoindol-1-one, 2,3-dihydro-2-(4-hydroxyphenyl)-5,6-dimethoxy-

Classification

Derivative of isoindoline, phenolic compound

Physical properties

White solid, soluble in organic solvents (e.g. ethanol, dimethyl sulfoxide)

Uses

Pharmaceutical and medical research (potential anti-inflammatory and antioxidant properties), natural product with biological activity.

Upstream product

• 123-30-8 4-amino-phenol 
• 4821-94-7 4,5-dimethoxyphthalic anhydride 
• 862211-41-4 N-(4-hydroxyphenyl)-5,6-dimethoxyphthalimide 

Downstream Products

• 680576-46-9 N-[4-(3-chloropropoxy)phenyl]-5,6-dimethoxy-1-oxo-isoindoline 
• 862211-42-5 N-[4-(2,3-epoxypropoxy)phenyl]-5,6-dimethoxy-1-oxo-isoindoline 

Relevant academic research and scientific papers

Synthesis of 4-(1-oxo-isoindoline) and 4-(5,6-dimethoxy-1-oxo-isoindoline)- substituted phenoxypropanolamines and their β1-, β2-adrenergic receptor binding studies

Phenoxypropanolamines with 1-oxo-isoindoline (12-16) and 5,6-dimethoxy-1-oxo-isoindoline groups (17-20) at the para position were synthesized. β1, β2-Adrenergic receptor binding affinities for the synthesized compounds were tested and compared with propranolol and atenolol. It was found that the incorporation of para-amidic functionality within the 1-oxo-isoindoline ring and 5,6-dimethoxy-1-oxo- isoindoline ring system led to a high degree of cardioselectivity in the phenoxypropanolamines. Two of the compounds 12 and 20 possessed β1-adrenergic receptor affinity comparable with that of atenolol and both showed a better cardioselectivity than atenolol. Both 12 and 20 are undergoing further pharmacological evaluation.