680587-79-5Relevant academic research and scientific papers
Synthesis of novel derivatives of 5-(4,6-dimethyl-2-pyrimidinylsulfanyl) methyl-1,2,4-triazole-3-thione
Burbuliene,Jakubkiene,Mekuskiene,Vainilavicius
, p. 2431 - 2440 (2003)
Alkylation of 5-(4,6-dimethyl-2-pyrimidinylsulfanyl)methyl-1,2,4-triozole- 3-thione (2) with various alkyl halides, 4-chlorophenacyl bromide, chloroacetic acid, and α-chloroacetanilide afforded S-substituted 1,2,4-triazoles (3-11). 3-Carboxymethylsulfanyl-5-(4,6-dimethyl-2-pyrimidinylsulfanyl)methyl-1, 2,4-triazole (9), in the presence of acetic anhydride, was cyclized to 6-(4,6-dimethyl-2-pyrimidinyl-sulfanyl)methylthiazolo[3,2-b][1,2,4]triazol-3(2H) -one (12). The later condensed with aromatic aldehydes to give 6-(4,6-dimethyl-2-pyrimidinylsulfanyl)methyl-6-[(1-aryl)methylidene]thiazolo[3, 2-b][1,2,4]triazol-3(2H)-ones (13, 14) and under treatment with aniline underwent ring-disclosure reaction to yield 3-(phenylcarbamoyl)methylsulfanyl-5- (4,6-dimethyl-2-pyrimidinylsulfanyl)methyl-1,2,4-triazole (11).
