68060-49-1

Basic information

• Product Name: SUBSTANCE P (1-7)
• Synonyms: ARG-PRO-LYS-PRO-GLN-GLN-PHE;H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-OH;RPKPQQF;SUBSTANCE P (1-7);SUBSTANCE P FRAGMENT 1-7;L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-OH;L-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-OH;1-7-Substance P
• CAS NO: 68060-49-1
• Molecular Formula: C₄₁H₆₅N₁₃O₁₀
• Molecular Weight: 900.04
• Product Categories: Peptide
• Mol File: 68060-49-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.49±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C
• PKA: 3.49±0.10(Predicted)
• CAS DataBase Reference: SUBSTANCE P (1-7)(CAS DataBase Reference)
• NIST Chemistry Reference: SUBSTANCE P (1-7)(68060-49-1)
• EPA Substance Registry System: SUBSTANCE P (1-7)(68060-49-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 68060-49-1(Hazardous Substances Data)

Usage

General Description

Substance P (1-7) is a small fragment derived from a larger peptide molecule called Substance P, which is commonly present in the central nervous system and plays a significant role in pain perception and transmission. Being a Neuropeptide, this fragment generates several biological effects similar to its parent substance and is involved in various physiological processes including inflammation, stress responses and blood pressure regulation. It interacts with various receptors and can influence behaviors, pain sensitivity, mood, and memory. This chemical's effects and uses are an area of active research currently due to its potential in treating conditions such as stress, depression, and post-traumatic stress disorder(PTSD).

Upstream product

• 33507-63-0 substance P 

Downstream Products

• 803730-09-8 C₅₄H₈₃N₁₅O₁₂ 

Relevant articles and documents

Major metabolites of substance P degraded by spinal synaptic membranes antagonize the behavioral response to substance P in rats

Substance P (SP) was degraded by synaptic membranes of rat spinal cord. Cleavage products were separated by reversed phase high performance liquid chromatography and identified by amino acid composition analyses. Major products of SP were phenylalanine, SP(1-4), SP(1-6), SP(1-7), SP(10-11), and SP(8-9). Both the degradation of SP and the accumulation of the major cleavage products were strongly inhibited by a metal chelator, o- phenanthroline, and also by specific inhibitors of endopeptidase-24.11, thiorphan, and phosphoramidon. Thus, endopeptidase-24.11 plays a major role in SP degradation in the rat spinal cord. N-Terminal fragments, SP(17) and SP(14), detected after incubation with spinal synaptic membranes were examined in vivo for antagonism against the scratching, biting, and licking response induced by intrathecal (IT) injection of SP (3.0 nmol) in rats. When IT coadministered with SP, SP(1-7) and SP(14) produced a significant inhibition of behavioral response to SP with ED50 of 135.0 pmol and 6.2 nmol, respectively. These results suggest that the degradation of SP in the spinal cord is not only responsible for inactivation of parent peptide, but may also lead to the formation of N-terminal SP-fragments which are shown to display a novel physiological function.