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SUBSTANCE P (1-7) is a small fragment derived from a larger peptide molecule called Substance P, which is commonly present in the central nervous system and plays a significant role in pain perception and transmission. As a neuropeptide, this fragment generates several biological effects similar to its parent substance and is involved in various physiological processes, including inflammation, stress responses, and blood pressure regulation. It interacts with various receptors and can influence behaviors, pain sensitivity, mood, and memory.

68060-49-1

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68060-49-1 Usage

Uses

Used in Pharmaceutical Industry:
SUBSTANCE P (1-7) is used as a potential therapeutic agent for managing conditions such as stress, depression, and post-traumatic stress disorder (PTSD) due to its influence on pain sensitivity, mood, and memory.
Used in Research Applications:
SUBSTANCE P (1-7) is used as a research tool to study the interactions with various receptors and its effects on physiological processes like inflammation, stress responses, and blood pressure regulation, which can help in understanding its potential applications in treating related conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 68060-49-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,0,6 and 0 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 68060-49:
(7*6)+(6*8)+(5*0)+(4*6)+(3*0)+(2*4)+(1*9)=131
131 % 10 = 1
So 68060-49-1 is a valid CAS Registry Number.

68060-49-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name Substance P Fragment 1-7

1.2 Other means of identification

Product number -
Other names 2-[[5-amino-2-[[5-amino-2-[[1-[6-amino-2-[[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:68060-49-1 SDS

68060-49-1Upstream product

68060-49-1Downstream Products

68060-49-1Relevant academic research and scientific papers

Major metabolites of substance P degraded by spinal synaptic membranes antagonize the behavioral response to substance P in rats

Sakurada, Chikai,Watanabe, Chizuko,Sakurada, Shinobu,Tan-No, Koichi,Sakurada, Tsukasa

, p. 1127 - 1132 (1999)

Substance P (SP) was degraded by synaptic membranes of rat spinal cord. Cleavage products were separated by reversed phase high performance liquid chromatography and identified by amino acid composition analyses. Major products of SP were phenylalanine, SP(1-4), SP(1-6), SP(1-7), SP(10-11), and SP(8-9). Both the degradation of SP and the accumulation of the major cleavage products were strongly inhibited by a metal chelator, o- phenanthroline, and also by specific inhibitors of endopeptidase-24.11, thiorphan, and phosphoramidon. Thus, endopeptidase-24.11 plays a major role in SP degradation in the rat spinal cord. N-Terminal fragments, SP(17) and SP(14), detected after incubation with spinal synaptic membranes were examined in vivo for antagonism against the scratching, biting, and licking response induced by intrathecal (IT) injection of SP (3.0 nmol) in rats. When IT coadministered with SP, SP(1-7) and SP(14) produced a significant inhibition of behavioral response to SP with ED50 of 135.0 pmol and 6.2 nmol, respectively. These results suggest that the degradation of SP in the spinal cord is not only responsible for inactivation of parent peptide, but may also lead to the formation of N-terminal SP-fragments which are shown to display a novel physiological function.

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