680612-08-2Relevant academic research and scientific papers
Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties
Murray, Iain A.,Krishnegowda, Gowdahalli,Dinatale, Brett C.,Flaveny, Colin,Chiaro, Chris,Lin, Jyh-Ming,Sharma, Arun K.,Amin, Shantu,Perdew, Gary H.
experimental part, p. 955 - 966 (2011/03/17)
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. However, the role of the AHR in normal physiology is still an area of intense investigation. For example, thi
Preparation and purification of 4-(indazol-3-yl) phenols
-
Page/Page column 5; 6, (2008/06/13)
The present invention concerns processes for the production and purification of compounds of the formula: where R1-R10 are as defined in the specification. Preferred processes of the invention utilize a lithium bis(trimethylsilyl)ami
Methods of treating inflammatory bowel disease using NF-kB inhibitors
-
Page/Page column 15; 16, (2010/02/11)
The present invention concerns a method of treating inflammatory bowel disease by diagnosing that a person is in need of treatment for inflammatory bowel disease and administering a therapeutically effective amount of a ligand which modulates NF-kB transc
SUBSTITUTED 4-(INDAZOL-3-YL)PHENOLS AS ESTROGEN RECEPTOR (ER) LIGANDS AND THEIR USE IN THE TREATMENT OF INFLAMMATORY DISEASES
-
Page 66; 74, (2008/06/13)
This invention provides compound of formulae I or II having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined in the specification or a pharmaceutically acceptable salt thereof which are useful for the treatment of the infla
