68074-16-8Relevant academic research and scientific papers
ORALLY EFFECTIVE ANTI-HYPERTENSIVE AGENTS
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, (2008/06/13)
Novel thiolester compounds are disclosed which are orally effective angiotensin converting enzyme inhibitors useful in the treatment of mammalian hypertension. They have the formula, EQU1 wherein Z denotes-B-A 2, R 1 is H or an acyl group, A 1 is a carboxylic acid containing at least one amino or imino-N-, A 2 is a carboxylic acid containing at least one amino or imino-N-or a lower alkyl ester or amide thereof, B is a 2-4 carbon backbone chain in mercapto linkage to S which includes a carbonyl or sulfonyl group joined in carboxamido or sulfonamido linkage, respectively, to A 2. Preferably A 2 includes a 4-6 membered C-N ring or a 5 membered ring of one N, one S and 3 C atoms.
Anti-hypertensive agents
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, (2008/06/13)
Novel inhibitors of angiotensin converting enzyme having the general formula R--A--S--Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.
Process for preparing 2-acetylthiomethyl-5-guanidinopentanoic acid
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, (2008/06/13)
A process is described for preparing 2-acetylthiomethyl-5-quanidinopentanoic acid by treating 2-acetylthiomethyl-5-aminopentanoic acid with 1-quanyl-3,5-dimethylpyrazole in a medium comprising a hydroxylated solvent.
Process for recovering 2-acetylthiomethyl-5-aminopentanoic acid
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, (2008/06/13)
A process is described for recovering 2-acetylthiomethyl-5-aminopentanoic acid from an impure acid addition salt thereof by treating the latter in a polar organic solvent with a base.
Amino acid derivatives
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, (2008/06/13)
A method for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprises administering an effective amount of a compound having the general formula STR1 Intermediates for the preparation of such compounds are also included.
AMINO ACID DERIVATIVES
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, (2008/06/13)
New substituted acyl derivatives of amino acids which have the general formula STR1 are useful as angiotensin converting enzyme inhibitors.
