68095-22-7

Basic information

• Product Name: Acetamide, N-[2-(chloroacetyl)phenyl]- (9CI)
• Synonyms: Acetamide, N-[2-(chloroacetyl)phenyl]- (9CI);N-[2-(2-chloroacetyl)phenyl]acetamide
• CAS NO: 68095-22-7
• Molecular Formula: C₁₀H₁₀ClNO₂
• Molecular Weight: 211.6449
• Product Categories: ACETYLHALIDE
• Mol File: 68095-22-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Acetamide, N-[2-(chloroacetyl)phenyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-[2-(chloroacetyl)phenyl]- (9CI)(68095-22-7)
• EPA Substance Registry System: Acetamide, N-[2-(chloroacetyl)phenyl]- (9CI)(68095-22-7)

Safety Data

• Hazardous Substances Data: 68095-22-7(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 64605-23-8 2'-amino-2-chloroacetophenone 
• 108-24-7 acetic anhydride 

Downstream Products

• 482-89-3 1H,1H'-2,2'-Biindolylidene-3,3'-dione 
• 38072-53-6 (Z)-2-(4-(dimethylamino)benzylidene)indolin-3-one 
• 38073-42-6 (2Z)-2-(phenylmethylidene)-2,3-dihydro-1H-indol-3-one 
• 1361967-99-8 1-acetyl-2-((4’-(trifluoromethoxy)biphenyl-4-yl)methylene)indolin-3-one 

Relevant articles and documents

Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB

Herein we report the screening of a small library of aurones and their isosteric counterparts, azaaurones and N-acetylazaaurones, against Mycobacterium tuberculosis. Aurones were found to be inactive at 20 μm, whereas azaaurones and N-acetylazaaurones emerged as the most potent compounds, with nine derivatives displaying MIC99 values ranging from 0.4 to 2.0 μm. In addition, several N-acetylazaaurones were found to be active against multidrug-resistant (MDR) and extensively drug-resistant (XDR) clinical M. tuberculosis isolates. The antimycobacterial mechanism of action of these compounds remains to be determined; however, a preliminary mechanistic study confirmed that they do not inhibit the mycobacterial cytochrome bc1 complex. Additionally, microsomal metabolic stability and metabolite identification studies revealed that N-acetylazaaurones are deacetylated to their azaaurone counterparts. Overall, these results demonstrate that azaaurones and their N-acetyl counterparts represent a new entry in the toolbox of chemotypes capable of inhibiting M. tuberculosis growth.

Identification, design and biological evaluation of heterocyclic quinolones targeting plasmodium falciparum Type II NADH:Quinone oxidoreductase (PfNDH2)

Following a program undertaken to identify hit compounds against NADH:ubiquinone oxidoreductase (PfNDH2), a novel enzyme target within the malaria parasite Plasmodium falciparum, hit to lead optimization led to identification of CK-2-68, a molecule suitab