680993-10-6Relevant academic research and scientific papers
Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents
Ayerbe, Nathalie,Routier, Sylvain,Gillaizeau, Isabelle,Maiereanu, Carmen,Caignard, Daniel-Henry,Pierre, Alain,Leonce, Stephane,Coudert, Gerard
, p. 4670 - 4674 (2010)
We report the efficient synthesis and biological evaluation of new benzodioxinoindolocarbazoles heterocycles (BDCZs) designed as potential anticancer agents. Indolic substitution and maleimide variations were performed to design a new library of BDCZs and their cytotoxicity were evaluated on two representative cancer cell lines. Several derivatives have shown a marked cytotoxicity with IC50 values in the nanomolar range. Results are reported in this Letter.
