68100-39-0

Upstream product

• 123-54-6 acetylacetone 
• 100-46-9 benzylamine 
• 109-77-3 malononitrile 
• 154420-74-3 (E)-3-Amino-3-benzylaminoacrylnitril 

Downstream Products

• 893768-53-1 12-benzyl-2,4-dimethyl-11b,12-dihydropyrido[2',3':4,5]pyrimido[2,1-a]isoindole-5,7-dione 
• 893768-57-5 1-benzyl-2-(4-bromophenyl)-5,7-dimethyl-2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-one 

Relevant academic research and scientific papers

Novel synthesis of some new fluoerescent 2-amino-3-cyanopyridines

Novel synthesis of some new fluorescent 2-amino-3-cyanopyridines 2a-m in the presence of N-hydroxybenzamide or p-toluenesulfonic acid is described. Photophysical data including λAbs. and λFlu. of 2a-m in CH2Cl2,

Substituted 2-aminonicotinonitriles

Aminolysis of the cyanoketene-O,N-acetal 1 Z/E with the amines 2a,b leads to the E-configurated cyanoketeneaminals 3a,b. Compounds 3a,b are reacted with 1,3-biselectrophiles 4, 6a,b, 9 HCl, 12, 13, 15a,b, 17, and 19 to yield the N2-substituted 2-aminonicotinonitriles 5, 7, 8, 10, 11, 14, 16, and 20. Reaction of some 2-aminonicotinonitriles with an α-phenylethyl substituent in position 2 (14b, 16a, 8a, 20b, 5 and 8b) with PPA leads to the primary 2-aminonicotinonitriles 21a-f.