681001-63-8 Usage
Uses
Used in Pharmaceutical Synthesis:
1H-Indazole-3-carbonitrile, 4,6-dinitro-1-phenylis utilized as a key intermediate in the synthesis of pharmaceuticals for its ability to be a part of organic reactions that lead to the creation of new drug molecules. Its unique structure allows for the development of compounds with potential therapeutic properties.
Used in Agrochemical Synthesis:
In the agrochemical industry, 1H-Indazole-3-carbonitrile, 4,6-dinitro-1-phenylis employed as a building block in the synthesis of various agrochemicals, contributing to the development of new pesticides or other agricultural products that can enhance crop protection and yield.
Used in Antimicrobial Applications:
1H-Indazole-3-carbonitrile, 4,6-dinitro-1-phenylhas been investigated for its antimicrobial properties, making it a potential candidate for use as an antimicrobial agent in various applications where resistance to existing treatments is a concern.
Used in Anticancer Research:
1H-Indazole-3-carbonitrile, 4,6-dinitro-1-phenylhas shown potential in anticancer research, warranting further investigation into its use as a therapeutic agent against cancer. Its electrophilic nature may allow it to interact with biological targets in ways that could inhibit or kill cancer cells.
Used in Organic Reactions:
Due to its reactivity, 1H-Indazole-3-carbonitrile, 4,6-dinitro-1-phenylis used in various organic reactions, such as nucleophilic aromatic substitution, where it can be substituted by a nucleophile to form new compounds with different functional groups. This property is valuable in the synthesis of complex organic molecules.
Used in Palladium-Catalyzed Coupling Reactions:
1H-Indazole-3-carbonitrile, 4,6-dinitro-1-phenyl-'s electrophilic nature also makes it suitable for use in palladium-catalyzed coupling reactions, a class of chemical reactions widely used in organic chemistry to form carbon-carbon bonds. This application is crucial for the synthesis of a variety of organic compounds, including those with potential applications in materials science and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 681001-63-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,1,0,0 and 1 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 681001-63:
(8*6)+(7*8)+(6*1)+(5*0)+(4*0)+(3*1)+(2*6)+(1*3)=128
128 % 10 = 8
So 681001-63-8 is a valid CAS Registry Number.
681001-63-8Relevant academic research and scientific papers
Synthesis of 3-substituted 1-aryl-4,6-dinitro-1H-indazoles based on picrylacetaldehyde and their behavior in nucleophilic substitution reactions
Starosotnikov,Kachala,Lobach,Vinogradov,Shevelev
, p. 1782 - 1790 (2007/10/03)
A method for the synthesis of 1-aryl-3-formyl-4,6-dinitro-1H-indazoles by the reaction of picrylacetaldehyde with aryldiazonium salts followed by intramolecular cyclization of the resulting picrylglyoxal monoarylhydrazones was developed. Various 4,6-dinitro-1-phenyl-1H-indazoles substituted in position 3 were prepared via transformations involving the formyl group of 3-formyl-4,6-dinitro-1-phenyl-1H-indazole. 3-R-4,6-Dinitro-1-phenyl-1H- indazoles (R = CHO, CN, 1,3-dioxolan-2-yl) react regiospecifically with anionic O-, S-, and N-nucleophiles, in particular, with replacement of only the 4-NO2 group. Thus previously unknown 3-R-4-Nu-6-nitro-1-phenyl-1H- indazoles were synthesized (Nu is a nucleophile residue).
