68101-25-7

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 57-13-6 urea 

Downstream Products

• 70273-18-6 5-bromo-4-(4-chloro-phenyl)-oxazol-2-ylamine 
• 1590443-70-1 4-(4-(4-chlorophenyl)oxazol-2-yl)thiomorpholine-3,5-dione 
• 1590443-77-8 4-(4-(4-chlorophenyl)oxazol-2-yl)-1,1-dioxothiomorpholine-3,5-dione 
• 1616983-90-4 3'-(4-(4-chlorophenyl)oxazol-2-ylamino)-5'-(4-chlorophenyl)-4',5'-dihydropyrazole-1'-carbothioamide 
• 1616983-99-3 3'-(4-(4-chlorophenyl)oxazol-2-ylamino)-5'-(4-chlorophenyl)-1'H-pyrazole-1'-carbothioamide 
• 1616984-08-7 5'-(4-chlorophenyl)-N-(4-(4-chlorophenyl)oxazol-2-yl)-1'-(4-(4-chlorophenyl)thiazol-2-yl)-1'H-pyrazol-3'-amine 
• 1616983-83-5 C₁₈H₁₂Cl₂N₂O₂ 

Relevant academic research and scientific papers

Molecular properties prediction, synthesis, and antimicrobial activity of bis(azolyl)sulfonamidoacetamides

A library of bis(azolyl)sulfonamidoacetamides was prepared by the reaction of azolylsulfonylamines with azolylchloroacetamides in the presence of pyridine/4-(dimethylamino)pyridine (DMAP) under ultrasonication. The reaction proceeded well with DMAP, resulting in a higher yield of the products. The antimicrobial activity of the compounds indicated that N-{5-[N-(2-{[4-(4-chloro-1H-pyrrol-2-yl)-1H-imidazol-2-yl)amino}-2-oxoethyl)sulfamoyl]-4-phenylthiazol-2-yl}benzamide (22a), N-{5-[N-(2-{[4-(4-chloro-1H-pyrrol-2-yl)-1H-imidazol-2-yl]amino}-2-oxoethyl)sulfamoyl]-4-(4-chlorophenyl)thiazol-2-yl}benzamide (22c), and N-{5-[N-(2-{[4-(4-chloro-1H-pyrrol-2-yl)-1H-imidazol-2-yl]amino}-2-oxoethyl)sulfamoyl]-4-(4-chloro-phenyl)-1H-imidazol-2-yl}benzamide (24c) exhibited a low minimal inhibitory concentration (MIC) against Bacillus subtilis, equal to the standard drug, chloramphenicol. Compounds 22c and 24c also showed low MICs against Aspergillus niger, equal to the standard drug, ketoconazole. The molecular properties of the synthesized molecules were studied to identify druglikeness properties of the target compounds. On the basis of molecular properties prediction, 19a, 19b, 20b, 20c, 21a–c, 22b, 22c, and 23a–c can be treated as drug candidates.

Synthesis, Characterization, and Antioxidant Activity of a New Class of Amido linked Azolyl Thiophenes

A new class of amido linked azolyl thiophenes was prepared from the synthetic intermediates azolyl amines and 5-chlorothiophene-2-carbonyl chloride adopting conventional and ultrasonication methodologies. It was observed that the reaction took place in shorter reaction times with higher yields under ultrasonication. The structures of the synthesized compounds were characterized by spectral parameters and also tested for antioxidant activity. Among all the tested compounds, methoxy substituted oxazolyl thiophene carboxamide (8c) displayed promising antioxidant activity. Besides, the electron donating groups on the phenyl ring enhanced the antioxidant activity when compared with the electron withdrawing groups.

Synthesis and Antimicrobial Activity of Azolyl Pyrimidines

A new class of azolyl pyrimidines linked by diamino sulfone moiety was prepared and studied their antimicrobial activity. Chloro-substituted and nitro-substituted thiazolyl pyrimidines (9c and 9e) showed excellent antibacterial activity against Bacillus subtilis, while imidazolyl pyrimidines (10c and 10e) exhibited promising antifungal activity against Aspergillus niger.

PROCESS FOR THE PREPARATION OF OXAZOLE DERIVATIVES

A production method of a compound represented by the formula wherein R1 and R2 are each a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R3 is an electron-withdr