68104-58-5

Upstream product

• 110-85-0 piperazine 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 589-16-2 4-aminoethylbenzene 

Downstream Products

• 131027-99-1 1-{2-[4-(4-Ethyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-pyrrolidin-2-one 
• 129010-82-8 3-(4-(4-ethylphenyl)-1-piperazinyl)propionitrile 
• 174877-45-3 2-Bromo-1-[4-(4-ethyl-phenyl)-piperazin-1-yl]-propan-1-one 
• 1208252-49-6 N-(5-tert-butyl-2-methylphenyl)-2-[4-(4-ethylphenyl)piperazin-1-yl]-7-methyl-7H-purin-6-amine 
• 129010-99-7 N-{3-[4-(4-Ethyl-phenyl)-piperazin-1-yl]-propyl}-2-methoxy-5-sulfamoyl-benzamide 
• 55931-65-2 3-(4-(4-ethylphenyl)-1-piperazinyl)propylamine 

Relevant academic research and scientific papers

Synthesis of potent and selective dopamine D4 antagonists as candidate radioligands

A series of dopamine D4 antagonists was synthesized and evaluated as potential candidates for development as positron emission tomography (PET) radioligands. All new compounds display high affinity and selectivity for the D4 receptors and compounds 5b, 5d, and 5e were identified as candidates for radioligand development.

Practical method for parallel synthesis of diversely substituted 1-phenylpiperazines

A simple and practical method to prepare 'libraries' of substituted 1-phenylpiperazine building blocks in parallel format has been developed.

PIPERIDIN-4-YLPIPERAZINE COMPOUNDS FOR THE TREATMENT OF HCV INFECTION

The invention relates to new piperazine-pieridine compounds having anti-viral activity and particularly anti-HCV activity. The invention further relates to pharmaceutical compositions comprising compounds according to the invention.