68104-59-6

Basic information

• Product Name: 4-[4-(1-methylethyl)phenyl]piperazine
• Synonyms: 4-[4-(1-methylethyl)phenyl]piperazine
• CAS NO: 68104-59-6
• Molecular Weight: 204.315
• Mol File: 68104-59-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[4-(1-methylethyl)phenyl]piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(1-methylethyl)phenyl]piperazine(68104-59-6)
• EPA Substance Registry System: 4-[4-(1-methylethyl)phenyl]piperazine(68104-59-6)

Safety Data

• Hazardous Substances Data: 68104-59-6(Hazardous Substances Data)

Upstream product

• 99-88-7 4-Isopropylaniline 
• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 586-61-8 4-iso-propylbromobenzene 
• 1121599-93-6 C₁₈H₂₈N₂O₂ 

Downstream Products

• 1198592-61-8 methyl 1-(2-{4-[4-(1-methylethyl)phenyl]-1-piperazinyl}-2-oxoethyl)-3-phenyl-1H-indole-6-carboxylate 

Relevant articles and documents

Discovery of small molecules that inhibit melanogenesis via regulation of tyrosinase expression

5,6,7,8-Tetrahydro-4H-cyclohepta[d]isoxazole derivatives were synthesized and evaluated as a novel class of inhibitors for α-melanocyte-stimulating hormone (α-MSH) induced melanogenesis in a mouse melanoma B16F10 cell line. Compound 8e (IC50 = 0.67 μM), 8h (IC50 = 1.01 μM) and 9b (IC50 = 0.99 μM) exhibited a potent inhibitory activity approximately 85- to 126-fold greater than kojic acid, a well-known potent inhibitor. A biochemical study indicates that the activity of this series should be displayed via down-regulation of the expression of tyrosinase.