68108-01-0Relevant academic research and scientific papers
Syntheses of S-Substituted L-Homocysteine Derivatives by Cystathionine γ-Lyase of Streptomyces phaeochromogenes
Kanzaki, Hiroshi,Kobayashi, Michihiko,Nagasawa, Toru,Yamada, Hideaki
, p. 391 - 398 (2007/10/02)
Cystationine γ-lyase from Streptomyces phaeochromogenes catalyzes not only the α,γ-elimination rection of L-cystathionine, but also the γ-replacement reaction of L-homoserine in the presence of thiol compounds.Substrates for the enzyme in the γ-replacement reaction were examined.It was found that D-cysteine, L- and D-homocysteine, and 3- and 2-mercaptopropionate served as preferable substrates in the γ-replacement reaction.D-Allocystathionine, L- and mesohomolanthionine, S-carboxyethyl-L-homocysteine and S-methylcarboxymethyl-L-homocysteine were enzymatically synthesized from L-homoserine and the corresponding thiol compounds.The thus synthesized S-substituted L-homocysteine derivatives were isolated from large scale reaction mixtures and identified physicochemically.
