681145-06-2

Basic information

• Product Name: 2-[2-(2-methoxy-benzyloxyamino)-ethyl]-isoindole-1,3-dione
• CAS NO: 681145-06-2
• Molecular Weight: 326.352
• Mol File: 681145-06-2.mol

Chemical Properties

• CAS DataBase Reference: 2-[2-(2-methoxy-benzyloxyamino)-ethyl]-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2-methoxy-benzyloxyamino)-ethyl]-isoindole-1,3-dione(681145-06-2)
• EPA Substance Registry System: 2-[2-(2-methoxy-benzyloxyamino)-ethyl]-isoindole-1,3-dione(681145-06-2)

Safety Data

• Hazardous Substances Data: 681145-06-2(Hazardous Substances Data)

Upstream product

• 612-16-8 (2-methoxyphenyl)methanol 
• 574-98-1 2-(2-bromoethyl)isoindoline-1,3-dione 
• 161146-52-7 O-[(2-methoxyphenyl)methyl]hydroxylamine 

Downstream Products

• 681152-53-4 1-(2-methoxy-benzyloxy)-4,5-dihydro-1H-imidazole-2-thiol 
• 681147-10-4 N-(2-amino-ethyl)-O-(2-methoxy-benzyl)-hydroxylamine 

Relevant articles and documents

1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists

Screening of the Roche compound depository led to the identification of (1-benzyloxy-4,5-dihydro-1H-imidazol-2-yl)-butyl amine 4, a structurally novel NR1/2B subtype selective NMDA receptor antagonist. The structure-activity relationships developed in this series resulted in the discovery of a novel class of potent and selective NMDA receptor blockers displaying activity in vivo.