681152-08-9Relevant academic research and scientific papers
Ti(III)-catalyzed radical cyclization of 6,7-epoxygeranyl acetate
Fuse, Shinichiro,Hanochi, Malcoln,Doi, Takayuki,Takahashi, Takashi
, p. 1961 - 1963 (2007/10/03)
The reductive cyclization of epoxygeranyl acetate (1) was investigated using a catalytic amount of Cp2TiCl with various additives. The newly developed Cp2TiCl-Mn-lutidine·HCl-BEt3 system was found to be as effective as the reported stoichiometric system to afford the cyclized dehydro products 4 and 5 with 72% selectivity.
Stereo- and regio-selective Ti-mediated radical cyclization of epoxy-alkenes: Synthesis of the A and C ring synthons of paclitaxel
Nakai, Kazuoki,Kamoshita, Miyuki,Doi, Takayuki,Yamada, Haruo,Takahashi, Takashi
, p. 7855 - 7857 (2007/10/03)
We have developed a practical synthetic route for the A and C rings of paclitaxel. The key reaction is a Ti-mediated radical cyclization of an epoxyalkene.
