681235-15-4Relevant academic research and scientific papers
Synthesis, in-vitro anticancer screening and radiosensitizing evaluation of some new N-(quinoxalin-2-yl)benzenesulfonamide derivatives
Ghorab,Ragab,Heiba,El-Gazzar,El-Gazzar
, p. 46 - 52 (2012)
The objective of this work is to synthesize and investigate the anticancer activity of a new series of sulfaquinoxaline derivatives by incorporating biologically active moieties (thiourethane, thiazole, imidazole, imidazopyrimidine, imidazopyrimido-pyrimidine, thienopyrimidine, benzopyrimidinone, benzothiazole, thiazole and pyridine moieties). All the newly synthesized compounds were evaluated for their in-vitro anticancer activity against human liver cell line (HEPG2). All the tested compounds showed comparable activity to that of the reference drug 5-fluorouracil (IC 50=40 M), and the most potent compounds were found to be compounds 4 and 17 (IC50=4.29 and 11.27 M, respectively). On the other hand, the most potent compounds 4 and 17 were evaluated as radiosensitizing agents. Georg Thieme Verlag KG Stuttgart · New York.
