681248-91-9

Upstream product

• 122775-35-3 3,4-Dimethoxyphenylboronic acid 
• 66224-66-6 adenine 
• 155579-45-6 5-amino-1-(3,4-dimethoxyphenyl)-4-cyanoimidazole 

Downstream Products

• 1089184-66-6 9-(3,4-dimethoxyphenyl)-8-(3,4,5-trimethoxyphenyl)-adenine 
• 1089184-74-6 9-(3,4-dimethoxyphenyl)-N₆,8-bis(3,4,5-trimethoxyphenyl)-adenine 
• 1089184-81-5 9-(3,4-dimethoxyphenyl)-N₆,N₆,8-tris(3,4,5-trimethoxyphenyl)-adenine 
• 1089184-63-3 9-(3,4-dimethoxyphenyl)-8-(4-methoxyphenyl)-adenine 
• 1089184-71-3 9-(3,4-dimethoxyphenyl)-N₆,8-bis(4-methoxyphenyl)-adenine 
• 1089184-78-0 9-(3,4-dimethoxyphenyl)-N₆,N₆,8-tris(4-methoxyphenyl)-adenine 
• 1089184-64-4 8,9-bis(3,4-dimethoxyphenyl)-adenine 
• 1089184-73-5 N₆,8,9-tris(3,4-dimethoxyphenyl)-adenine 
• 1089184-79-1 N₆,N₆,8,9-tetrakis(3,4-dimethoxyphenyl)-adenine 

Relevant academic research and scientific papers

Synthesis of 6,8,9-tri- and 2,6,8,9-tetrasubstituted purines by a combination of the Suzuki cross-coupling, N-arylation, and direct C-H arylation reactions

(Chemical Equation Presented) Novel practical methodology of synthesis of a several types of di-, tri-, and tetraarylpurine derivatives by a combination of regioselective Suzuki cross-coupling reactions and/or Cu-catalyzed N-arylation with direct C-H arylations was developed. 6,8-Diaryl- and 2,6,8-triaryl-9- isopropylpurines were prepared by one or two cross-couplings of 6-chloro- or 2,6-dichloro-9-isopropylpurine with arylboronic acids followed by Pd-catalyzed C-H arylation by aryl halides to position 8. 6-Chloropurine and adenine underwent Cu-catalyzed N-arylation to position 9 with boronic acids, followed by cross-coupling with AlMe3 and/or C-H arylation to obtain 8,9-diaryl-6-methylpurines or 8,9-diaryladenines (accompanied by products of partial N-arylation of adenine in position 6). The methodology is suitable for construction of small libraries of modified purines.

Synthesis of 9-aryl-6-aminopurines from 5-amino-1-aryl-1H-imidazole-4- carbonitriles

5-Amino-1-aryl-1H-imidazole-4-carbonitriles were converted into 9-aryl-6-aminopurines via imidates formation at treating with CH(OEt) 3 and Ac2O followed by reaction with ammonia.