681253-61-2

Upstream product

• 16227-22-8 glycyl-L-phenylalanine methyl ester 
• 106624-70-8 methyl (2S)-2-[[2-(t-butoxycarbonylamino)acetyl]amino]-3-phenylpropanoate 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 808771-75-7 (S)-2-{2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-3-phenyl-propionic acid methyl ester 

Downstream Products

• 681254-36-4 (2S,3R)-2-Benzyloxycarbonylamino-3-((S)-2-{2-[(S)-2-{[(S)-1-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-3-phenyl-propionyloxy)-butyric acid methyl ester 
• 681254-20-6 (2S,3R)-2-Benzyloxycarbonylamino-3-((S)-2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-3-phenyl-propionyloxy)-butyric acid methyl ester 

Relevant academic research and scientific papers

Novel antibiotics: Second generation macrocyclic peptides designed to trap Holliday junctions

Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on th

A progressive synthetic strategy for class B synergimycins

Described are the syntheses of four macrocyclic peptides that are the core structure of class B synergimycins, and the synthesis of a final class B derivative. Our synthetic route to these synergimycin derivatives allows the incorporation of amino acid su