681253-71-4Relevant academic research and scientific papers
A progressive synthetic strategy for class B synergimycins
Robinson, Jennifer L.,Taylor, Rachel E.,Liotta, Lisa A.,Bolla, Megan L.,Azevedo, Enrique V.,Medina, Irene,McAlpine, Shelli R.
, p. 2147 - 2150 (2007/10/03)
Described are the syntheses of four macrocyclic peptides that are the core structure of class B synergimycins, and the synthesis of a final class B derivative. Our synthetic route to these synergimycin derivatives allows the incorporation of amino acid su
Novel antibiotics: macrocyclic peptides designed to trap Holliday junctions.
Bolla, Megan L,Azevedo, Enrique V,Smith, Jason M,Taylor, Rachel E,Ranjit, Dev K,Segall, Anca M,McAlpine, Shelli R
, p. 109 - 112 (2007/10/03)
[reaction: see text] Described are the syntheses of eight macrocyclic peptides designed to trap Holliday junctions in bacteria, thereby inhibiting bacterial growth. These macrocycles were designed from linear dimerized hexapeptides that bind to the C-2 sy
