68128-21-2Relevant academic research and scientific papers
Enantioselective Hydrogenation of Ketones using Different Metal Complexes with a Chiral PNP Pincer Ligand
Garbe, Marcel,Wei, Zhihong,Tannert, Bianca,Spannenberg, Anke,Jiao, Haijun,Bachmann, Stephan,Scalone, Michelangelo,Junge, Kathrin,Beller, Matthias
supporting information, p. 1913 - 1920 (2019/03/13)
The synthesis of different metal pincer complexes coordinating to the chiral PNP ligand bis(2-((2R,5R)-2,5-dimethyl-phospholanoethyl))amine is described in detail. The characterized complexes with Mn, Fe, Re and Ru as metal centers showed good activities regarding the reduction of several prochiral ketones. Comparing these catalysts, the non-noble metal complexes produced best selectivities not only for aromatic substrates, but also for different kinds of aliphatic ones leading to enantioselectivities up to 99% ee. Theoretical investigations elucidated the mechanism and rationalized the selectivity. (Figure presented.).
CHIRAL METAL COMPLEX COMPOUNDS
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Page/Page column 18; 19; 21; 23; 24; 25, (2018/11/10)
The invention comprises novel chiral metal complex compounds of the formula (I) wherein M, PR2, R3 and R4 are outlined in the description, its stereoisomers, in the form as a neutral complex or a complex cation with a suitable counter ion. The chiral metal complex compounds can be used in asymmetric reactions, particularly in asymmetric reductions of ketones, imines or oximes.
Highly enantioselective transfer hydrogenation of fluoroalkyl ketones
Sterk, Damjan,Stephan, Michel,Mohar, Barbara
, p. 5935 - 5938 (2007/10/03)
(Chemical Equation Presented) The asymmetric transfer hydrogenation of fluoroalkyl ketones mediated by [Ru(η6-arene)((S,S)-R 2NSO2DPEN)] catalysts using HCO2H-Et 3N afforded the corresponding alcohols
Enantioselective Rhodium(I)-Catalyzed Hydrogenation of Trifluoromethyl Ketones
Kuroki, Yoshichika,Sakamaki, Yuko,Iseki, Katsuhiko
, p. 457 - 459 (2007/10/03)
(Matrix Presented) The asymmetric hydrogenation of trifluoromethyl ketones to yield chiral α-trifluoromethyl alcohols with enantiomeric excesses up to 98% was achieved in the presence of chiral rhodium-(amidephosphine-phosphinite) complexes.
Asymmetric Synthesis at Nitrogen by Oxidation of Imines with m-Chloroperbenzoic Acid in the Presence of Optically Active Carbinols. Absolute Stereochemistry of Chiral Alcohol-Imine-Peracid Solvates
Bucciarelli, Maria,Forni, Arrigo,Moretti, Irene,Torre, Giovanni
, p. 2152 - 2161 (2007/10/02)
Optically active oxaziridines, stable at the asymmetric nitrogen atom, have been obtained by oxidation of imines with m-chloroperbenzoic acid in the presence of chiral carbinols.The optical purity of the reaction products increases on decreasing the tempe
