681280-85-3Relevant academic research and scientific papers
Novel endoperoxides: Synthesis and activity against Candida species
Macreadie, Peter,Avery, Thomas,Greatrex, Ben,Taylor, Dennis,Macreadie, Ian
, p. 920 - 922 (2007/10/03)
Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic Candida species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural sim
Novel Endoperoxide Antimalarials: Synthesis, Heme Binding, and Antimalarial Activity
Taylor, Dennis K.,Avery, Thomas D.,Greatrex, Ben W.,Tiekink, Edward R. T.,Macreadie, Ian G.,Macreadie, Peter I.,Humphries, Adam D.,Kalkanidis, Martha,Fox, Emma N.,Klonis, Nectarios,Tilley, Leann
, p. 1833 - 1839 (2007/10/03)
We report the synthesis of a series of novel epoxy endoperoxide compounds that can be prepared in high yields in one to three steps from simple starting materials. Some of these compounds inhibit the growth of Plasmodium falciparum in vitro. Structure-act
