681433-44-3

Upstream product

• 122-78-1 phenylacetaldehyde 
• 596093-06-0 (2S)-ethoxy-(4S)-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-pyran 

Downstream Products

• 1219937-62-8 C₁₃H₁₄O₂ 
• 904315-25-9 6-[1-(tert-butyl-diphenyl-silanyloxy)-2-phenyl-ethyl]-3,6-dihydro-2H-pyran-2-ol 
• 904315-27-1 (R)-6-[(R)-1-(tert-Butyl-diphenyl-silanyloxy)-2-phenyl-ethyl]-5,6-dihydro-pyran-2-one 
• 904315-26-0 (R)-6-[(R)-1-(tert-Butyl-diphenyl-silanyloxy)-2-phenyl-ethyl]-3,6-dihydro-pyran-2-one 
• 904315-24-8 tert-butyl-[1-(6-ethoxy-5,6-dihydro-2H-pyran-2-yl)-2-phenyl-ethoxy]-diphenyl-silane 

Relevant academic research and scientific papers

Efficient Asymmetric Synthesis of 2,6-Disubstituted 2H-Dihydropyrans via a Catalytic Hetero-Diels-Alder/Allylboration Sequence

[4 + 2] Cycloaddition of (E)-3-borylacrolein 1 with ethyl vinyl ether, catalysed by chromium complex (1R,25) or (15,2R) 2, led to the corresponding cycloadducts with high diastereo- and enantioselectivities. Further reaction with aldehydes offers an attractive asymmetric route to synthetically useful substituted 3,4-dihydro-2H-pyrans.

First synthesis of (+)-8-methoxygoniodiol and its analogue, 8-deoxygoniodiol, using a three component strategy

We have described the first total synthesis of the natural product, (+)-8-methoxygoniodiol, and its analogue, 8-deoxygoniodiol using a catalytic asymmetric hetero-Diels-Alder/allylboration sequence involving three partners. The cytotoxic activity of these

Catalytic enantioselective three-component hetero-[4+2] cycloaddition/allylboration approach to α-hydroxyalkyl pyrans: Scope, limitations, and mechanistic proposal

This article describes the design and optimization of a catalytic enantioselective three-component hetero-[4 + 2] cycloaddition/allylboration reaction between 3-boronoacrolein, enol ethers, and aldehydes to afford α-hydroxyalkyl dihydropyrans, The key sub