681478-75-1

Basic information

• Product Name: 4-Quinolinecarboxamide, 7-fluoro-3-methoxy-2-phenyl-N-[(1S)-1-phenylpropyl]-
• CAS NO: 681478-75-1
• Molecular Formula: C26H23FN2O2
• Molecular Weight: 414.479
• Mol File: 681478-75-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Quinolinecarboxamide, 7-fluoro-3-methoxy-2-phenyl-N-[(1S)-1-phenylpropyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinolinecarboxamide, 7-fluoro-3-methoxy-2-phenyl-N-[(1S)-1-phenylpropyl]-(681478-75-1)
• EPA Substance Registry System: 4-Quinolinecarboxamide, 7-fluoro-3-methoxy-2-phenyl-N-[(1S)-1-phenylpropyl]-(681478-75-1)

Safety Data

• Hazardous Substances Data: 681478-75-1(Hazardous Substances Data)

Upstream product

• 4079-52-1 methoxymethyl phenyl ketone 
• 324-03-8 6-fluoroisatin 
• 3789-59-1 (R)-1-phenylpropylamine 

Relevant articles and documents

Synthesis and biological evaluation of novel fluoro and iodo quinoline carboxamides as potential ligands of NK-3 receptors for in vivo imaging studies

In order to develop radioligands of human NK-3 receptor (hNK-3r) for imaging studies by positron emission tomography (PET) or single photon emission computed tomography (SPECT), a new series of fluoro- and iodo-quinoline carboxamides were synthesized and evaluated in a target receptor binding assay. Compared to the unsubstituted parent compound SB 223 412 (Ki= 27nM±9), affinity was not altered for the analogues 1c and 2c bearing a fluorine in position 8 (Ki～24-27nM), and was only slightly reduced for compounds 1b, 2b, 1e and 2e fluorinated or iodinated at the position 7 (Ki～49-67nM). A drastic reduction in binding (K i>115nM) was observed for all other halogenated compounds 1a, 2a, 1d, 2d, 1f and 2f.