681482-80-4

Usage

Uses

Used in Pharmaceutical Industry:
1-[4-(tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenoxy)piperidine is used as a key intermediate in the synthesis of Delamanid (D230660) for its role in inhibiting mycolic acid synthesis. This makes it a vital component in the production of a medication that demonstrates potent in-vitro and in-vivo activity against drug-resistant strains of Mycobacterium tuberculosis, offering a potential solution for combating multi-drug resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB).

Upstream product

• 36603-49-3 4-(tetrahydropyran-2'-yloxy)-1-bromobenzene 
• 287952-67-4 4-(4-(trifluoromethoxy)phenoxy)piperidine 

Downstream Products

• 866109-93-5 4-(4-(4-trifluoromethoxy-phenoxy)piperidin-1-yl)phenol para-toluenesulfonic acid salt 
• 681482-81-5 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine 

Relevant academic research and scientific papers

Preparation method of aromatic amine intermediate

The invention discloses a preparation method of an aromatic amine intermediate. The preparation method comprises the following steps: 1, in a polar aprotic solvent, under the presence of a catalyst, aligand and an alkali, a compound of formula III and a c

Method for preparing Delmanid high-purity intermediate by one-pot method

The invention relates to a method for preparing a Delmanid high-purity intermediate by a one-pot method, and belongs to the technical field of chemical medicines. The preparation method comprises thefollowing steps: (1) carrying out a Buchwald-Hartwig ary

Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles

In an effort to develop potent new antituberculosis agents that would be effective against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis, we prepared a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxaz