68149-78-0

Usage

Uses

Used in Food Industry:
2-Propenal, 3-(3,4-dihydroxyphenyl)is used as a natural antioxidant in the food industry to extend the shelf life of plant-based foods such as fruits, vegetables, and grains. Its antioxidant properties help to prevent oxidation and spoilage, maintaining the freshness and quality of these foods.
Used in Health Industry:
2-Propenal, 3-(3,4-dihydroxyphenyl)is used as a dietary supplement in the health industry due to its antioxidant properties. It helps to neutralize free radicals in the body, promoting overall health and well-being.
Used in Pharmaceutical Industry:
2-Propenal, 3-(3,4-dihydroxyphenyl)is used as an antimicrobial agent in the pharmaceutical industry to combat various types of bacteria and infections. Its antimicrobial properties make it a promising candidate for the development of new antibiotics.
2-Propenal, 3-(3,4-dihydroxyphenyl)is also used as an anti-inflammatory agent in the pharmaceutical industry to reduce inflammation and alleviate pain. Its anti-inflammatory properties make it a potential candidate for the treatment of various inflammatory conditions.

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 72898-29-4 4-propenylcatechol 

Downstream Products

• 20649-42-7 coniferaldehyde 
• 545442-98-6 dihydrocaffeyl aldehyde 

Relevant academic research and scientific papers

In vivo Structure-Activity Relationship of Dihydromethysticin in Reducing Nicotine-Derived Nitrosamine Ketone (NNK)-Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice

Lung cancer is the leading cause of cancer-related deaths and chemoprevention should be developed. We recently identified dihydromethysticin (DHM) as a promising candidate to prevent NNK-induced lung tumorigenesis. To probe its mechanisms and facilitate its future translation, we investigated the structure-activity relationship of DHM on NNK-induced DNA damage in A/J mice. Twenty DHM analogs were designed and synthesized. Their activity in reducing NNK-induced DNA damage in the target lung tissues was evaluated. The unnatural enantiomer of DHM was identified to be more potent than the natural enantiomer. The methylenedioxy functional moiety did not tolerate modifications while the other functional groups (the lactone ring and the ethyl linker) accommodated various modifications. Importantly, analogs of high structural similarity to DHM with distinct efficacy in reducing NNK-induced DNA damage have been identified. They will serve as chemical probes to elucidate the mechanisms of DHM in blocking NNK-induced lung carcinogenesis.

Method for preparing olefine aldehyde by catalyzing terminal alkyne or terminal conjugated eneyne and diphosphine ligand used in method

The invention discloses a method for preparing olefine aldehyde by catalyzing terminal alkyne or terminal conjugated eneyne and a diphosphine ligand used in the method. According to the invention, indole-substituted phosphoramidite diphosphine ligand which is stable in air and insensitive to light is synthesized by utilizing a continuous one-pot method, and the indole-substituted phosphoramidite diphosphine ligand and a rhodium catalyst are used for jointly catalyzing to successfully achieve a hydroformylation reaction of aromatic terminal alkyne and terminal conjugated eneyne under the condition of synthesis gas for the first time, so that an olefine aldehyde structure compound can be rapidly and massively prepared, and particularly, a polyolefine aldehyde structure compound which is more difficult to synthesize in the prior art can be easily prepared and synthesized, and a novel method is provided for synthesis and modification of drug molecules, intermediates and chemical products.