681490-95-9

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-chloro-1-[2-hydroxy-2-methyl-3-(4-nitrobenzoyloxy)]-propyl-4-nitroimidazole is used as an intermediate in the synthesis of Delamanid (D230660), a novel anti-tuberculosis medication. Delamanid is designed to inhibit mycolic acid synthesis, which is essential for the growth and survival of Mycobacterium tuberculosis, the causative agent of tuberculosis. (R)-2-chloro-1-[2-hydroxy-2-methyl-3-(4-nitrobenzoyloxy)]-propyl-4-nitroimidazole has demonstrated potent in-vitro and in-vivo activity against drug-resistant strains of Mycobacterium tuberculosis, making it a valuable asset in the fight against this challenging disease.

Upstream product

• 57531-37-0 2-chloro-4-nitro-1H-imidazole 
• 106268-96-6 (2R)-methyl-3-[4-nitrobenzoyl(oxy)]-1,2-epoxy-propane 
• 106268-95-5 (R)-glycidyl 4-nitrobenzoate 

Downstream Products

• 681490-91-5 (R)-2-chloro-1-(2,3-dihydroxy-2-methyl)-propyl-4-nitroimidazole 

Relevant academic research and scientific papers

SUBSTITUTED 1,2,3-TRIAZOL-1-YL-METHYL-2,3-DIHYDRO-2-METHYL-6-NITROIMIDAZO[2,1-B]OXAZOLES AS ANTI-MYCOBACTERIAL AGENTS AND A PROCESS FOR THE PREPARATION THEREOF

The present invention relates to new generation of triazole functionality containing 6-nitro-2,3-dihydroimidazooxazole agents for general formula I, their method of preparation and their use as drugs for treatment of tuberculosis, MDR-TB and XDR-TB either

Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: In vitro, structure-activity relationship, pharmacokinetics and in vivo evaluation

The nitroimidazole scaffold has attracted great interest in the last decade, which ultimately led to the discovery of the successful drug Delamanid for multi-drug resistant tuberculosis (MDR-TB). Herein, we report medicinal chemistry on a 6-nitro-2,3-dihy

6-NITRO-2,3-DIHYDROIMIDAZO[2,1-b]OXAZOLES AND A PROCESS FOR THE PREPARATION THEREOF

The present invention relates to newer generation of triazoles, tetrazoles, isoxazoles, urea and sulphonamide functionalities containing 6-nitro-2, 3-dihydronitroimidazooxazoles agents of formula 1, their method of preparation, and their use as drugs for

Synthesis and antituberculosis activity of a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles

In an effort to develop potent new antituberculosis agents that would be effective against both drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis, we prepared a novel series of optically active 6-nitro-2,3-dihydroimidazo[2,1-b]oxaz