681512-07-2Relevant academic research and scientific papers
3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists
Biju, Purakkattle,Taveras, Arthur G.,Yu, Younong,Zheng, Junying,Hipkin, R. William,Fossetta, James,Fan, Xuedong,Fine, Jay,Lundell, Daniel
scheme or table, p. 1434 - 1437 (2009/10/15)
A series of potent and selective 3,4-diamino-1,2,5-thiadiazoles were prepared and found to show excellent binding affinities towards CXCR2 receptor.
3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists
Biju, Purakkattle,Taveras, Arthur,Yu, Younong,Zheng, Junying,Chao, Jianhua,Rindgen, Diane,Jakway, James,Hipkin, R. William,Fossetta, James,Fan, Xuedong,Fine, Jay,Qiu, Hongchen,Merritt, J. Robert,Baldwin, John J.
, p. 228 - 231 (2008/09/17)
A series of novel and potent 3,4-diamino-2,5-thiadiazole-1-oxides were prepared and found to show excellent binding affinities for CXCR2 and CXCR1 receptors and excellent inhibitory activity of Gro-α and IL-8 mediated in vitro hPMN MPO release of CXCR2 an
