68161-28-4

Downstream Products

• 66783-77-5 4'-tert-butyl-5'-oxo-3'-(4-trifluoromethyl-phenyl)-spiro[fluorene-9,2'-oxazolidine]-4'-carbonitrile 
• 66783-85-5 fluoren-9-ylidene-(4-trifluoromethyl-phenyl)-amine oxide 

Relevant academic research and scientific papers

Synthesis of spirofluorenes of biological interest

1'-Substituted spiro[fluorene-9,3'-pyrrolidine-2',5'-diones], 1',1''' - (1,4-piperazinediyldimethylene)bis[spiro[fluorene-9,3'- pyrrolidine-2',5'-dione]], and 1'-arylspiro[fluorene-9,3'-pyrrolidines] were synthesized from spiro[fluorene-9,3'-tetrahydrofuran-2',5'-dione]. The rat passive cutaneous anaphylaxis assay showed that 1 compound possessed slight antiallergic activity. Synthesis of 3-substituted 1- aryl-4-oxospiro[azetidine-2,9'-fluorenes] and 1,1'-p-phenylenebis[4- oxospiro[azetidine-2,9'-fluorenes]] was achieved via the reaction of appropriate N-fluorenylideneanilines with tert-butylcyanoketene and cyclopentamethyleneketene, respectively.