68167-57-7

Upstream product

• 586-76-5 4-Bromobenzoic acid 
• 1670-14-0 benzamidine monohydrochloride 

Downstream Products

• 65004-20-8 5-(4-bromophenyl)-3-phenyl-1,2,4-oxadiazole 
• 80473-19-4 1-(4-bromobenzoyl)-2-phenyl-4-piperidino-5-hydroxy-4,5-dihydroimidazole 
• 74460-75-6 1-(4-bromobenzoyl)-2-phenyl-4,5-dipiperidinoimidazoline 

Relevant academic research and scientific papers

A metal-free tandem approach to prepare structurally diverse N-heterocycles: Synthesis of 1,2,4-oxadiazoles and pyrimidinones

A metal-free one-pot approach to the diversity oriented synthesis of N-heterocycles, 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones is described via carboxamidation of amidines with aryl carboxylic acids and aryl propargylic acids. The reactions occur at room temperature forming N-acylamidines which undergo tandem nucleophilic addition-deamination- intramolecular cyclisation to give the corresponding heterocyclic compounds in good to excellent yields. This one pot approach has led to the successful synthesis of the drug lead molecule, ataluren, 3-(5-(2-fluorophenyl)-1,2,4- oxadiazol-3-yl) benzoic acid in two steps. the Partner Organisations 2014.