68178-69-8Relevant academic research and scientific papers
Superelectrophiles in Synthesis: Preparation of Aromatic Imides
Kennedy, Sean H.,Schaeff, Mark N.,Klumpp, Douglas A.
, p. 14133 - 14140 (2019)
Aromatic carboxylic acids are found to undergo reactions with isocyanates, wherein triflic acid promotes the formation of aromatic imide products in fair to good yields. It is proposed that the carboxylic acid group directs the isocyanate electrophile to
1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides used as anti-inflammatory agents
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, (2008/06/13)
1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides, nuclear unsubstituted and substituted, are prepared by reacting the appropriate homophthalimide with potassium cyanate. Secondary carboxamides are prepared by reacting homophthalimide with appropriate isocyanates, and tertiary carboxamides are prepared by aminolysis of 4-carbalkoxy compounds, which are in turn prepared by alcoholysis of the corresponding 4-carboxanilides. Corresponding 5,6,7,8-tetrahydro compounds are similarly prepared. The various 2-substituted homophthalimides are prepared by reacting homophthalic acid with appropriate amine. The 4-carboxamides are anti-inflammatory agents.
