68180-24-5 Usage
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Chemical compound
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Belongs to the class of purines
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Important components of nucleic acids
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Found in naturally occurring substances
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Characterized by a 6-chloro substitution on the purine ring
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Dodecyl chain attached to the 9-position
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Used in research and pharmaceutical development
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Starting material for the synthesis of purine derivatives
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Potential biological activities
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Applications in developing new drugs
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Ability to interact with biological targets
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Subject of study in organic chemistry and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 68180-24-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,8,1,8 and 0 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 68180-24:
(7*6)+(6*8)+(5*1)+(4*8)+(3*0)+(2*2)+(1*4)=135
135 % 10 = 5
So 68180-24-5 is a valid CAS Registry Number.
68180-24-5Relevant academic research and scientific papers
Synthesis and anticonvulsant activity of novel purine derivatives
Wang, Shi-Ben,Jin, Peng,Li, Fu-Nan,Quan, Zhe-Shan
, p. 574 - 583 (2015/03/14)
A series of new purines containing triazole and other heterocycle substituents was synthesized and evaluated for their preliminary anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) and rotarod neurotoxicity (TOX) tests. Among the compounds studied, 9-decyl-6-(1H-1,2,4-triazol-1-yl)-9H-purine (5e) was the most potent compound, with a median effective dose of 23.4 mg/kg and a high protective index of more than 25.6 after intraperitoneal administration in mice. Compound 5e showed significant oral activity against MESinduced seizures in mice, with an ED50 of 39.4 mg/kg and a PI above 31.6. These results demonstrate that compound 5e possesses better anticonvulsant activity and is safer than the commercially available drugs carbamazepine and valproate in MES, scPTZ and TOX models.
