68181-01-1Relevant academic research and scientific papers
Hydrazide and hydrazine reagents as reactive matrices for MALDI-MS to detect gaseous aldehydes
Shigeri, Yasushi,Ikeda, Shinya,Yasuda, Akikazu,Ando, Masanori,Sato, Hiroaki,Kinumi, Tomoya
, p. 742 - 749 (2014)
The reagents 19 hydrazide and 14 hydrazine were examined to function as reactive matrices for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) to detect gaseous aldehydes. Among them, two hydrazide (2-hydroxybenzohydrazide and 3-hydroxy-2-naphthoic acid hydrazide) and two hydrazine reagents [2-hydrazinoquinoline and 2,4-dinitrophenylhydrazine (DNPH)] were found to react efficiently with carbonyl groups of gaseous aldehydes (formaldehyde, acetaldehyde and propionaldehyde); these are the main factors for sick building syndrome and operate as reactive matrices for MALDI-MS. Results from accurate mass measurements by JMS-S3000 Spiral-TOF suggested that protonated ion peaks corresponding to [M + H]+ from the resulting derivatives were observed in all cases with the gaseous aldehydes in an incubation, time-dependent manner. The two hydrazide and two hydrazine reagents all possessed absorbances at 337 nm (wavelength of MALDI nitrogen laser), with, significant electrical conductivity of the matrix crystal and functional groups, such as hydroxy group and amino group, being important for desorption/ ionization efficiency in MALDI-MS. To our knowledge, this is the first report that gaseous molecules could be derivatized and detected directly in a single step by MALDI-MS using novel reactive matrices that were derivatizing agents with the ability to enhance desorption/ionization efficiency. Copyright 2014 John Wiley & Sons, Ltd. Copyright
Studies on Cu (II) and Ni (II) sulphate chelates of benzyl, salicylic and acetyl salicylo-hydrazones
Aliyu
scheme or table, p. 312 - 315 (2010/09/04)
Six complexes of Cu(II) and Ni(II) sulphate of acetaldehyde, benzaldehyde and salicylic acid with salicylic hydrazide were synthesized and characterized. The hydrazone acts as neutral bidentate clones coordinating via the carbonyl oxygen and its azomethine nitrogen, while the sulphate ions are in the outer coordination sphere. The bioactivities of ligands were enhanced on complexation.
