68185-02-4

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 621-84-1 O-benzyl carbamate 
• 75-52-5 nitromethane 
• 295365-34-3 ethyl benzyloxycarbonylamino(toluene-4-sulfonyl)acetate 
• 68185-07-9 N-Carbobenzoxy-2-acetoxyalaninaethylester 

Downstream Products

• 50685-13-7 ethyl (Z)-α-N-benzyloxycarbonyl-α,β-didehydrophenylalaninate 
• 1139270-28-2 Cbz-Cys[(Z)-2-carbomethoxyethenyl]-OEt 
• 70533-61-8 3-Azido-2-(benzyloxycarbonyl)aminoacrylat 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF 2-AZABICYCLO[3.3.0]OCTANE-3-CARBOXYLIC ACID DERIVATIVES

The present invention is aimed at a process for the preparation of compounds of the general formula (I) through the hydrogeneration of cyclization of the intermediates of the formula (II)

A new and convenient method for the synthesis of dehydroamino acids starting from ethyl N-Boc- and N-Z-α-tosylglycinates and various nitro compounds

Ethyl N-Boc- and N-Z-α-tosylglycinates, which were readily available from t-butyl or benzyl carbamate, ethyl glyoxylate, and sodium p- toluenesulfinate in formic acid, were reacted with a variety of nitro compounds in the presence of a base to afford the corresponding α,β- didehydroamino acid derivatives in good yields. Eventually, it was found that the (Z)-isomer was predominantly formed in the present method.