68185-98-8Relevant academic research and scientific papers
Chemoselective Amide-Forming Ligation Between Acylsilanes and Hydroxylamines Under Aqueous Conditions
Deng, Xingwang,Zhou, Guan,Tian, Jing,Srinivasan, Rajavel
supporting information, p. 7024 - 7029 (2020/12/29)
We report the facile amide-forming ligation of acylsilanes with hydroxylamines (ASHA ligation) under aqueous conditions. The ligation is fast, chemoselective, mild, high-yielding and displays excellent functional-group tolerance. Late-stage modifications of an array of marketed drugs, peptides, natural products, and biologically active compounds showcase the robustness and functional-group tolerance of the reaction. The key to the success of the reaction could be the possible formation of the strong Si?O bond via a Brook-type rearrangement. Given its simplicity and efficiency, this ligation has the potential to unfold new applications in the areas of medicinal chemistry and chemical biology.
Synthesis of aryl and alkyl acylsilanes using trimethyl(tributylstannyl)silane
Geng, Feng,Maleczka Jr., Robert E.
, p. 3113 - 3114 (2007/10/03)
Palladium catalyzed coupling of acid chlorides and trimethyl(tribuhfistannyl)silane proves to be a convenient method for the preparation of both aromatic and aliphatic acylsilanes.
