681853-21-4

Basic information

• Product Name: (3-nitrophenyl)(4-(p-tolyl)piperazin-1-yl)methanone
• Synonyms: (3-nitrophenyl)(4-(p-tolyl)piperazin-1-yl)methanone
• CAS NO: 681853-21-4
• Molecular Weight: 325.367
• Mol File: 681853-21-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-nitrophenyl)(4-(p-tolyl)piperazin-1-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3-nitrophenyl)(4-(p-tolyl)piperazin-1-yl)methanone(681853-21-4)
• EPA Substance Registry System: (3-nitrophenyl)(4-(p-tolyl)piperazin-1-yl)methanone(681853-21-4)

Safety Data

• Hazardous Substances Data: 681853-21-4(Hazardous Substances Data)

Upstream product

• 121-92-6 3-nitrobenzoic acid 
• 13078-14-3 1-(4-methylphenyl)piperazine hydrochloride 
• 121-90-4 m-nitrobenzoic acid chloride 
• 106-49-0 p-toluidine 

Relevant articles and documents

Discovery of aroyl piperazine derivatives as IKr & I Ks dual inhibitors for cardiac arrhythmia treatment

Combined blockade of IKr and IKs potassium channels is considered to be a promising therapeutic strategy for arrhythmia. In this study, we designed and synthesized 15 derivatives through modifying the hit compound 7 that was discovered by screening in-house database by whole-patch clamp technique. All of the compounds were evaluated on CHO and HEK 293 cell lines stably expressing hERG (IKr) and hKCNQ1/KCNE1 (IKs) potassium channels, and half of them exhibited improved dual IKr and IKs inhibitory effects compared to the hit compound. Compounds 7a and 7b with potent dual inhibitory activities were selected for further in vivo evaluations. Due to the preferable pharmacological behaviors, compound 7a deserved further optimization as a promising lead compound.