68192-58-5Relevant academic research and scientific papers
Structure guided lead generation for M. Tuberculosis thymidylate kinase (Mtb TMK): Discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors
Naik, Maruti,Raichurkar, Anandkumar,Bandodkar, Balachandra S.,Varun, Begur V.,Bhat, Shantika,Kalkhambkar, Rajesh,Murugan, Kannan,Menon, Rani,Bhat, Jyothi,Paul, Beena,Iyer, Harini,Hussein, Syeed,Tucker, Julie A.,Vogtherr, Martin,Embrey, Kevin J.,McMiken, Helen,Prasad, Swati,Gill, Adrian,Ugarkar, Bheemarao G.,Venkatraman, Janani,Read, Jon,Panda, Manoranjan
, p. 753 - 766 (2015)
M. tuberculosis thymidylate kinase (Mtb TMK) has been shown in vitro to be an essential enzyme in DNA synthesis. In order to identify novel leads for Mtb TMK, we performed a high throughput biochemical screen and an NMR based fragment screen through which
Synthesis of 4-Methylthio-2(1H)-pyridone Derivatives Using Ketene Dithioacetals
Tominaga, Yoshinori,Kawabe, Masanori,Hosomi, Akira
, p. 1325 - 1331 (2007/10/02)
Reaction of various active methylene compounds with ketene dithioacetals, bis(methylthio)methylenemalononitrile (1a) and bis(methylthio)methylenecyanoacetamide (1b) gave the corresponding 3-cyano-4-methylthio-2(1H)-pyridone derivatives.The transformation
