6820-59-3

Basic information

• Product Name: 1,2-Cyclopropanedicarbonyl dichloride, (1R-trans)- (9CI)
• Synonyms: 1,2-Cyclopropanedicarbonyl dichloride, (1R-trans)- (9CI)
• CAS NO: 6820-59-3
• Molecular Formula: C₅H₄Cl₂O₂
• Molecular Weight: 166.99
• Product Categories: ACIDHALIDE
• Mol File: 6820-59-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Cyclopropanedicarbonyl dichloride, (1R-trans)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclopropanedicarbonyl dichloride, (1R-trans)- (9CI)(6820-59-3)
• EPA Substance Registry System: 1,2-Cyclopropanedicarbonyl dichloride, (1R-trans)- (9CI)(6820-59-3)

Safety Data

• Hazardous Substances Data: 6820-59-3(Hazardous Substances Data)

Usage

General Description

1,2-Cyclopropanedicarbonyl dichloride, (1R-trans)- (9CI) is a chemical compound with the chemical formula C5H4Cl2O2. It is a dichloride derivative of cyclopropane and is in the trans configuration. It is commonly used as a chemical intermediate in the synthesis of pharmaceuticals and agrochemicals. 1,2-Cyclopropanedicarbonyl dichloride, (1R-trans)- (9CI) is known for its reactivity and is used in organic synthesis for the preparation of various compounds. It is also used in the manufacturing of specialty chemicals and can be found in small quantities in certain industrial processes. Overall, 1,2-Cyclopropanedicarbonyl dichloride, (1R-trans)- (9CI) is a versatile and important chemical compound with various applications in the chemical industry.

Upstream product

• 3999-55-1 diethyl trans-cyclopropane-1,2-dicarboxylate 
• 58616-95-8 trans-1,2-cyclopropanedicarboxylic acid 

Downstream Products

• 96149-00-7 (1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester 
• 3187-76-6 (trans)-cyclopropane-1,2-diamine dihydrochloride 
• 53187-82-9 (trans-cyclopropane-1,2-diyl)dimethanol 
• 35974-53-9 (+/-)-trans-2-dimethylcarbamoyl-cyclopropanecarboxylic acid 

Relevant articles and documents

ALKYLBORONIC ACIDS AS ARGINASE INHIBITORS

Provided are alkylboronic acids as arginase inhibitors represented by formula (I), or a pharmaceutically acceptable salt, stereoisomer, tautomer, or prodrug thereof and a pharmaceutical composition comprising said compounds.

CYCLOPROPYL-CONTAINING POLYAMINE ANALOGS AS DISEASE THERAPIES

This disclosure relates to specific polyamine analogs and methods of treating cancer using polyamine analogs. The polyamine analogs have cyclopropyl groups in their internal segments.

Photodecarbonylation of chiral cyclobutanones

Triplet photosensitized irradiation of 2(S),3(R)-bis[(benzoyloxy)methyl]cyclobutanone gave optically pure (-)E-1(S),2(S)-bis(benzoyloxymethyl)cyclopropaneas a major product in the nonpolar fraction along with its stereoisomer and cycloelimination products. The absolute stereochemistry of the chiral cyclopropane was established by independent synthesis and X-ray crystal structure determination of a synthetic precursor. The distribution of decarbonylation and cycloelimination products was inversely dependent on the concentration of the substrate. Irradiation of the same ketone in tetrahydrofuran or benzene gave mostly cycloelimination products. Addition of Michler's ketone increased the ratio of photodecarbonylation, suggesting a triplet state pathway for this process. This was corroborated by the addition of dicyanoethylene, which showed significant quenching of photodecarbonylation. Irradiation of 2(S)-[(benzoyloxy)methyl]cyclobutane in acetone gave the corresponding cyclopropane as the principal product.