68200-22-6Relevant academic research and scientific papers
Fluoro derivatives of retinal illuminate the decisive role of the C 12-H element in photoisomerization and rhodopsin activation
Bovee-Geurts, Petra H. M.,Fernandez, Isabelle Fernandez,Liu, Robert S. H.,Mathies, Richard A.,Lugtenburg, Johan,DeGrip, Willem J.
experimental part, p. 17933 - 17942 (2010/04/01)
Rhodopsin, the visual pigment of the vertebrate rod cell, is among the best investigated members of the G-protein-coupled receptor family. Within this family a unique characteristic of visual pigments is their covalently bound chromophore, 11-cis retinal,
Preparation of (all-E)- and (11Z)-12-haloretinals and (11Z,13Z)- and (13Z)-14-haloretinals by the C15 + C5 route - Exploring the possibility of preparing any retinoid rationally chemically modified at any position in the conjugated t
Wang, Yajie,Lugtenburg, Johan
, p. 5100 - 5110 (2007/10/03)
In this paper we describe how chemically modified ylides can be prepared by electrophilic substitution in a simple way. A subsequent Horner-Emmons reaction gives access to (all-E)- and (HZ)-12-chloro-, -12-bromo-, and -12-iodoretinal. It could be expected
