68206-04-2

Basic information

• Product Name: 3-Chloro-4-methylpyridazine
• Synonyms: 3-CHLORO-4-METHYLPYRIDAZINE;3-Chloro-4-methyl-1,2-diazine;3-Chloro-4-methylpyridazine 97%;3-Chloro-4-methylpyridazine97%;Pyridazine, 3-chloro-4-methyl-
• CAS NO: 68206-04-2
• Molecular Formula: C₅H₅ClN₂
• Molecular Weight: 128.56
• Product Categories: Halides;Pyrazines, Pyrimidines & Pyridazines;Pyridazine series;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Pyridazine
• Mol File: 68206-04-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 46-47 °C
• Boiling Point: 254.65 °C at 760 mmHg
• Flash Point: 132.443 °C
• Appearance: /
• Density: 1.235 g/cm³
• Vapor Pressure: 0.027mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.54±0.10(Predicted)
• CAS DataBase Reference: 3-Chloro-4-methylpyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-methylpyridazine(68206-04-2)
• EPA Substance Registry System: 3-Chloro-4-methylpyridazine(68206-04-2)

Safety Data

• Hazardous Substances Data: 68206-04-2(Hazardous Substances Data)

Usage

Uses

3-Chloro-4-methylpyridazine is a useful intermediate for the synthesis of pesticides and anti-viral drugs.

InChI:InChI=1/C5H5ClN2/c1-4-2-3-7-8-5(4)6/h2-3H,1H3

Upstream product

• 105537-47-1 ethyl 2-methyl-4,4-diethoxybutanoate 
• 105537-87-9 4-methyl-4,5-dihydro-3(2H)-pyridazinone 
• 61892-47-5 α-methyl-γ-hydroxybutyrolactone 
• 33471-40-8 4-methylpyridazin-3(2H)-one 

Downstream Products

• 90568-15-3 3-amino-4-methylpyridazine 
• 82426-93-5 1-(4-methylpyridazin-3-yl)hydrazine 

Relevant articles and documents

SUBSTITUTED AMINO HETEROCYCLES AS VR-1 ANTAGONISTS FOR TREATING PAIN

The present invention provides compounds of formula I: in which: one of T1and T4 is N and the other is C; T2 and T3 are independently N or C(CH2)nR2; X, Y and Z are independently N or C(CH2)nR3; R1 is Ar1 or R1 is C1-6alkyl optionally substituted with one or two groups Ar1; Ar1 is an optionally substituted cyclohexyl, piperidinyl, piperazinyl, morpholinyl, adamantyl, phenyl, naphthyl, a six-membered heteroaromatic ring containing one, two or three nitrogen atoms, a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one O or S atom being present, or a nine- or ten-membered bicyclic heteroaromatic ring in which phenyl or a six-membered heteroaromatic ring as defined above is fused to a six-or five-membered heteroaromatic ring as defined above; Ar is an optionally substituted phenyl, a six-membered heteroaromatic ring containing one, two or three nitrogen atoms or a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, Ar being optionally substituted by one, two or three groups chosen from halogen, CF3, OCF3, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, nitro, cyano, isonitrile, hydroxy, C1-6alkoxy, C1-6alkylthio, -NR6R7, -CONR6R7, -COH, CO2H, C1-6alkoxycarbonyl, haloC1-6alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl, C1-6alkylcarbonyl and a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, optionally substituted by C1-6alkyl, halogen, amino, hydroxy or cyano; or a pharmaceutically acceptable salt thereof as a VR-1 ligand; pharmaceutical compositions comprising it; its use in therapy; use of it in the manufacture of a medicament to treat pain; and methods of treating subjects suffering from pain.