68208-25-3

Basic information

• Product Name: 3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL
• Synonyms: RARECHEM AK ML 0439;3-AMINO-3-(3-CHLOROPHENYL)-1-PROPANOL;3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL;DL-BETA-(3-CHLOROPHENYL)ALANINOL;DL--(3-Chlorophenyl)alaninol;3-(3-CHLOROPHENYL)-DL-BETA-ALANINOL ;REF DUPL: DL-beta-(3-chlorophenyl)alaninol;Benzenepropanol, .gamma.-amino-3-chloro-
• CAS NO: 68208-25-3
• Molecular Formula: C₉H₁₂ClNO
• Molecular Weight: 185.65
• Mol File: 68208-25-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 327.9 °C at 760 mmHg
• Flash Point: 152.1 °C
• Appearance: /
• Density: 1.216 g/cm³
• Vapor Pressure: 7.93E-05mmHg at 25°C
• Refractive Index: 1.574
• CAS DataBase Reference: 3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL(68208-25-3)
• EPA Substance Registry System: 3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL(68208-25-3)

Safety Data

• Hazardous Substances Data: 68208-25-3(Hazardous Substances Data)

Usage

General Description

3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL is a chemical compound with the molecular formula C9H12ClNO. It is a white to off-white crystalline solid with a molecular weight of 187.65 g/mol. 3-AMINO-3-(3-CHLORO-PHENYL)-PROPAN-1-OL belongs to the class of organic compounds known as phenylpropanes, which are compounds containing a phenylpropane moiety. It is commonly used in the synthesis of pharmaceuticals and other organic compounds. This chemical has important biological activities, including antimicrobial and anti-inflammatory properties, making it a valuable compound for various industrial and research applications.

InChI:InChI=1/C9H12ClNO/c10-8-3-1-2-7(6-8)9(11)4-5-12/h1-3,6,9,12H,4-5,11H2

Upstream product

• 68208-21-9 3-amino-3-(3-chloro-phenyl)-propionic acid 
• 587-04-2 m-Chlorobenzaldehyde 

Downstream Products

• 677006-20-1 acetic acid 3-(3-chloro-phenyl)-3-thioacetylamino-propyl ester 
• 677006-26-7 N-[1-(3-chloro-phenyl)-3-hydroxy-propyl]-thioacetamide 
• 677006-31-4 4-(3-chloro-phenyl)-2-methyl-5,6-dihydro-4H-[1,3]thiazine 
• 677006-15-4 acetic acid 3-acetylamino-3-(3-chloro-phenyl)-propyl ester 

Relevant articles and documents

BENZOPYRAZOLE COMPOUND USED AS RHO KINASE INHIBITOR

The invention relates to a benzopyrazole compound used as RHO kinase inhibitor, a pharmaceutical composition and uses thereof for preparing an RHO kinase inhibiting drug, and more specifically to said compound of formula (I-1), a pharmaceutically acceptable salt and isomer thereof.

Base-induced Sommelet–Hauser rearrangement of N-(α-(2-oxyethyl)branched)benzylic glycine ester-derived ammonium salts via a chelated intermediate

The base-induced Sommelet–Hauser (S–H) rearrangement of N-(α-branched)benzylic glycine ester-derived ammonium salts 1 was investigated. When the α-branched substituent was a simple alkyl, such as a methyl or butyl, desired S–H rearrangement product 2 was obtained in low yield with formation of the [1,2] Stevens rearranged 4 and Hofmann eliminated products 5 and 6. However, when the α-branched substituent had a 2-oxy moiety, such as 2-acetoxyethyl or 2-benzoyloxyethyl, the yields of 2 were improved. These results could be explained by formation of chelated intermediate C that stabilizes the carbanionic ylide, and the subsequent initial dearomative [2,3] sigmatropic rearrangement would be accelerated. The existence of C was supported by mechanistic experiments. This enhancement effect is not very strong or effective; however, it will expand the synthetic usefulness of ammonium ylide rearrangements.