68210-19-5Relevant academic research and scientific papers
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: A new class of orally bioavailable nitric oxide synthase inhibitor
Ueda, Shigeo,Terauchi, Hideo,Yano, Akihiro,Ido, Motoharu,Matsumoto, Masashi,Kawasaki, Motoji
, p. 313 - 316 (2007/10/03)
In our search for a novel class of inducible nitric oxide synthase (iNOS) inhibitors, 1,3-oxazolidin-2-imine was found to weakly inhibit iNOS. Further modifications of this compound resulted in a remarkable increase in both the in vivo and in vitro inhibi
An efficient synthesis of a new series of acyclonucleosides starting from β-amino alcohols
Agami, Claude,Dechoux, Luc,Hamon, Louis,Melaimi, Mohand
, p. 6666 - 6669 (2007/10/03)
A series of new acyclonucleosides analogues 3 has been synthesized very efficiently in three steps starting from β-amino alcohols 1. The key step of this process is a nucleophilic substitution with various nucleophiles on 2,2'-anhydronucleosides 2. The chemo- and stereoselectivities of this reaction are discussed. AM1 calculations sustained the observed chemoselectivity.
