68219-69-2

Upstream product

• 68219-65-8 5-Benzamido-4-oxohexansaeureethylester 

Downstream Products

• 152534-08-2 7-(2-Chloro-5-methyl-imidazo[1,5-b]pyridazin-7-yl)-1-phenyl-heptan-1-ol 
• 152533-92-1 7-(2-Chloro-5-methyl-imidazo[1,5-b]pyridazin-7-yl)-1-phenyl-heptan-1-one 
• 152534-26-4 7-(2-Imidazol-1-yl-5-methyl-imidazo[1,5-b]pyridazin-7-yl)-1-phenyl-heptan-1-one 
• 152534-42-4 7-Oxo-8-phenyl-octanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide 
• 152534-38-8 Benzoic acid 5-[1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethylcarbamoyl]-pentyl ester 
• 152534-44-6 9-Oxo-9-phenyl-nonanoic acid [1-(6-oxo-1,6-dihydro-pyridazin-3-yl)-ethyl]-amide 

Relevant academic research and scientific papers

Synthesis and anti-HIV-1 activity of a series of imidazo[1,5- b]pyridazines

A series of substituted imidazo[1,5-b]pyridazines have been prepared and tested for inhibitory activity against the reverse transcriptase of HIV-1 (RT) and their ability to inhibit the growth of infected MT-4 cells. Crystal data are reported on two compounds, 15c and 33. From the structure-activity relationships developed within this and other series, it is proposed that key features of the interaction with RT include hydrogen-bond acceptor and aromatic π-orbital bonding with the imidazopyridazine nucleus and a benzoyl function separated from the heterocycle by a suitable spacer group. Exceptional activity against the reverse transcriptase of HIV-1 (IC50 = 0.65 nM) was obtained with a 2-imidazolyl-substituted derivative, 7-[2-(1H- imidazol-1-yl)-5-methylimidazo[1,5-b]pyridazin-7-yl]-1-phenyl-1-heptanone (33) which is attributed to additional binding of the imidazole sp2 nitrogen atom. A number of the compounds in this series also inhibit the replication of HIV-1 in vitro in MT-4 and C8166 cells at levels observed with the nucleoside AZT.