68221-96-5Relevant academic research and scientific papers
Fluorescence of cis-1-amino-2-(3-indolyl)cyclohexane-1-carboxylic acid: A single tryptophan χ1 rotamer model
Liu, Bo,Thalji, Reema K.,Adams, Paul D.,Fronczek, Frank R.,McLaughlin, Mark L.,Barkley, Mary D.
, p. 13329 - 13338 (2002)
A constrained derivative, cis-1-amino-2-(3-indolyl)cyclohexane-1-carboxylic acid, cis-W3, was designed to test the rotamer model of tryptophan photophysics. The conformational constraint enforces a single χ1 conformation, analogous to the χsub
Diversity-Oriented Synthesis of Bioactive Azaspirocycles
Lepovitz, Lance T.,Martin, Stephen F.
, (2019/11/03)
A collection of novel azaspirocyclic β-arylethylamines was prepared in good yield and excellent diastereoselectivity by an expedient strategy that features condensation of a cyclic ketone with an amino allylsilane and a tandem aza-Sakurai cyclization to generate several different spirocyclic N-heterocycles. Subsequent elaboration of the spirocyclic scaffold was achieved via Pictet-Spengler cyclizations, Suzuki cross-coupling reactions, N-functionalizations, and olefin refunctionalization reactions to create a diverse library of compounds, several of which have nanomolar affinity for the sigma 1 receptor and transmembrane protein 97 (TMEM97).
Addition of indoles to oxyallyl cations for facile access to α-indole carbonyl compounds
Tang, Qiang,Chen, Xingkuan,Tiwari, Bhoopendra,Chi, Yonggui Robin
supporting information; experimental part, p. 1922 - 1925 (2012/06/15)
A direct coupling of unprotected indoles and α-halo ketones via in situ generated oxyallyl cation intermediates is described. The reactions efficiently afford α-indole carbonyl compounds with good to quantitative yields.
Efficient and convenient C-3 functionalization of indoles through Ce(OAc)3/TBHP-mediated oxidative C-H bond activation in the presence of β-cyclodextrin
Hu, Yu Lin,Jiang, Hui,Lu, Ming
experimental part, p. 3079 - 3087 (2011/12/15)
A simple, green and efficient protocol for the selective C-3 functionalization of indoles with ketones and olefins via Ce(OAc) 3-TBHP mediated oxidative C-H activation in the presence of β-cyclodextrin in water has been developed. This atom-eco
6-Benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinoline compounds useful as PDE5 inhibitors
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Page/Page column 14; 29-30, (2008/12/07)
The compounds of formula (I) wherein R1 to R8 and R11 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof, and the stereoisomers of the compounds, the salts, the N-oxides of the compounds and the N-oxides of the salts thereof are effective inhibitors of the type 5 phosphodiesterase.
Stereocontrolled syntheses of some conformationally restricted analogs of serotonin
Ghosh, Arun,Wang, Wuyi,Freeman, Jeremiah P.,Althaust, John S.,VonVoigtlander, Philip F.,Scahill, Terrence A.,Mizsak, Stephen A.,Szmuszkovicz, Jacob
, p. 8653 - 8662 (2007/10/02)
Syntheses of serotonin analogs 2 and 3 are described including a case of retention in the Mitsunobu reaction. An unusual stereoselectivity in a reductive animation sequence is also described. Dopamine and serotonin activity of the eight analogs has been d
