68234-97-9Relevant articles and documents
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Reetz,M.T.,Schwellnus,K.
, p. 1455 - 1458 (1978)
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Lewis Acid-mediated α-tert-Alkylation of Carboxylic Acids and Carboxylic Esters
Reetz, Manfred T.,Schwellnus, Konrad,Huebner, Friedhelm,Massa, Werner,Schmidt, Roland E.
, p. 3708 - 3724 (2007/10/02)
Carboxylic acids and carboxylic esters can be α-tert-alkylated via the corresponding ketene silyl acetals 2 and 4 using tertiary alkyl halides or acetates in the presence of ZnCl2.The method is successful even if the products are sterically strained due t