682348-82-9Relevant academic research and scientific papers
Synthesis of 4-halophosphaisocoumarins via halocyclization of 2-(1-alkynyl)phenylphosphonates
Peng, Ai-Yun,Ding, Yi-Xiang
, p. 10303 - 10308 (2007/10/03)
A series of 4-halophosphaisocoumarins were prepared with high regioselectivity in good to excellent yields under mild conditions by the reaction of 2-(1-alkynyl)phenylphosphonic acid diesters with I2 in CHCl3 or ICl in CH2Cl2, or by the reaction of 2-(1-alkynyl)phenylphosphonic acid monoesters with NBS or NCS in DMF. Whether the alkynylphosphonates could cyclize or not was affected by the substituents, reaction solvents and electrophiles. A rationale for this reaction is discussed.
Synthesis of phosphaisocoumarins via iodocyclization
Peng, Ai-Yun,Ding, Yi-Xiang
, p. 1119 - 1121 (2007/10/03)
4-Iodophosphaisocoumarins can be prepared in good yield and with high regioselectivity under mild conditions by the reaction of o-(1-alkynyl) phenylphosphonates with I2 or ICI. The present reaction represents the first example of a phosphonate
