682357-49-9 Usage
Uses
Used in Organic Synthesis:
2-TERT-BUTYL-1H-INDOL-5-AMINE is utilized as a building block in organic synthesis for the creation of various chemical compounds. Its unique structure and reactivity make it a versatile component in the synthesis of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-TERT-BUTYL-1H-INDOL-5-AMINE is used as a key intermediate in the development of new drugs. Its presence in the molecular structure can influence the pharmacological properties of the final product, contributing to the discovery of novel therapeutic agents.
Used in Agrochemical Development:
2-TERT-BUTYL-1H-INDOL-5-AMINE also finds application in the agrochemical sector, where it serves as a precursor in the synthesis of pesticides and other agricultural chemicals. Its role in these compounds can enhance their effectiveness and selectivity in controlling pests and diseases.
Used in Materials Science:
2-TERT-BUTYL-1H-INDOL-5-AMINE's unique properties and reactivity make it a candidate for use in the development of new materials with specific characteristics. In materials science, 2-TERT-BUTYL-1H-INDOL-5-AMINE could be employed to create materials with tailored properties for various applications.
Research and Development:
Ongoing research into the biological and chemical properties of 2-TERT-BUTYL-1H-INDOL-5-AMINE is aimed at uncovering new applications and enhancing its utility in existing fields. This research is crucial for expanding the compound's use and understanding its full potential in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 682357-49-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,8,2,3,5 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 682357-49:
(8*6)+(7*8)+(6*2)+(5*3)+(4*5)+(3*7)+(2*4)+(1*9)=189
189 % 10 = 9
So 682357-49-9 is a valid CAS Registry Number.
682357-49-9Relevant academic research and scientific papers
SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS
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Page 25, (2008/06/13)
The present invention comprises indole-derivatives that are inhibitors of HCV. Composition comprising the compounds in combination with a pharmaceutically acceptable carrier are also disclosed, as are methods of using the compounds and compositions to inh
High-affinity inhibitors of dihydrofolate reductase: Antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size
Kuyper, Lee F.,Baccanari, David P.,Jones, Michael L.,Hunter, Robert N.,Tansik, Robert L.,Joyner, Suzanne S.,Boytos, Christine M.,Rudolph, Sharon K.,Knick, Vince,Wilson, H. Robert,Caddell, J. Marc,Friedman, Henry S.,Comley, John C. W.,Stables, Jeremy N.
, p. 892 - 903 (2007/10/03)
A series of 7,8-dialkylpyrrolo[3,2-f]quinazolines were prepared as inhibitors of dihydrofolate reductase (DHFR). On the basis of an apparent inverse relationship between compound size and antifungal activity, the compounds were designed to be relatively small and compact. Inhibitor design was aided by a GRID analysis of the three-dimensional structure of Candida albicans DHFR, which suggested that relatively small, branched alkyl groups at the 7- and 8-positions of the pyrroloquinazoline ring system would provide optimal interactions with a hydrophobic region of the protein. The compounds were potent inhibitors of fungal and human DHFR, with K(i) values as low as 7.1 and 0.1 pM, respectively, and were highly active against C. albicans and an array of tumor cell lines. In contrast to known lipophilic inhibitors of DHFR such as trimetrexate and piritrexim, members of this series of pyrroloquinazolines were not susceptible to P-glycoprotein-mediated multidrug resistance and also showed significant distribution into lung and brain tissue. The compounds were active in lung and brain tumor models and displayed in vivo activity against Pneumocystis carinii and C. albicans.
