68240-63-1

Usage

Uses

Used in Recreational Drug Industry:
4-MPPP is used as a psychoactive substance for its stimulant and empathogenic effects, providing users with euphoria, increased energy, and altered perception. However, its use is restricted due to its potential for abuse and dependence.

InChI:InChI=1/C18H22N2/c1-15-7-9-17(10-8-15)18(16-5-3-2-4-6-16)20-13-11-19-12-14-20/h2-10,18-19H,11-14H2,1H3

Upstream product

• 110-85-0 piperazine 
• 779-14-6 p-methyl-a-phenylbenzylchloride 

Downstream Products

• 118419-76-4 4-[4-(Phenyl-p-tolyl-methyl)-piperazin-1-yl]-butylamine 
• 661453-41-4 C₃₃H₃₄N₂O 
• 118420-31-8 (E)-3-(6-Methyl-pyridin-3-yl)-N-{4-[4-(phenyl-p-tolyl-methyl)-piperazin-1-yl]-butyl}-acrylamide 
• 118420-28-3 (E)-N-{4-[4-(Phenyl-p-tolyl-methyl)-piperazin-1-yl]-butyl}-3-pyridin-3-yl-acrylamide 

Relevant academic research and scientific papers

Structure-activity relationships of diphenylpiperazine N-type calcium channel inhibitors

A novel series of compounds derived from the previously reported N-type calcium channel blocker NP118809 (1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one) is described. Extensive SAR studies resulted in compounds with IC50 values in the range of 10-150 nM and selectivity over the L-type channels up to nearly 1200-fold. Orally administered compounds 5 and 21 exhibited both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain.