68243-21-0

Upstream product

• 125829-48-3 C₁₆H₁₄S 
• 884-09-3 phenyl thiobenzoate 
• 17336-59-3 1-tetralone tosylhydrazone 

Downstream Products

• 126745-21-9 1,1-dichloro-1a,2,3,7b-tetrahydro-7b-(phenylthio)-1H-cyclopropanaphthalene 
• 126745-25-3 1,2-dihydro-4-(phenylsulfonyl)naphthalene 
• 126745-30-0 3-bromo-1a,2,3,7b-tetrahydro-7b-(phenylsulfonyl)-1H-cyclopropanaphthalene 
• 126745-27-5 1a,2,3,7b-tetrahydro-7b-(phenylsulfonyl)-1H-cyclopropanaphthalene 
• 126745-28-6 1a,2,3,7b-tetrahydro-7b-(phenylthio)-1H-cyclopropanaphthalene 

Relevant academic research and scientific papers

Pd-Catalyzed Alkenyl Thioether Synthesis from Thioesters and N-Tosylhydrazones

A Pd-catalyzed alkenyl thioether synthesis was achieved using thioesters and N-tosylhydrazones as starting materials. The thioester acted as an efficient "sulfur source" for catalytic C-S bond formation using N-tosylhydrazone. This method gave Z-alkenyl thioethers with high diastereoselectivity (up to 99:1 diastereomeric ratio). This transformation displayed a wide functional group tolerance and was successfully applied to the late-stage derivatization of a pharmaceutical molecule to the corresponding alkenyl thioether.

Synthesis of vinyl sulfides and vinylamines through catalytic intramolecular hydroarylation in the presence of FeCl3 and AgOTf

A synthetic method was developed for the preparation of vinyl sulfides and vinylamines from arylalkynyl phenyl sulfides and sulfonamides. Under mild conditions, a catalytic intramolecular hydroarylation reaction was carried out in the presence of FeCl3 and AgOTf (OTf = trifluoromethanesulfonate) in 1,2-dichloroethane. A variety of 1,2-dihydronaphthalenes, 2H-chromenes, and 1,2-dihydroquinolines containing a phenylsulfenyl or N-phenyl-N-tosyl group on the sp2-hybridized benzylic carbon were prepared in good to excellent yields. The present method could be extended to the preparation of dihydropyrano[2,3-g]chromenes through a twofold Fe-catalyzed hydroarylation by a selective 6-endo mode. A synthetic method was developed for the preparation of vinyl sulfides and vinylamines. Arylalkynyl phenyl sulfides and sulfonamides underwent a catalytic intramolecular hydroarylation reaction to give 1,2-dihydronaphthalenes, 2H-chromenes, and 1,2-dihydroquinolines with a phenylsulfenyl or N-phenyl-N-tosyl group on the sp2-hybridized benzylic carbon. Copyright