68262-44-2Relevant academic research and scientific papers
Synthesis of new quinoline fused heterocycles such as benzo[h]-1,6- naphthyridines and pyrazolo[4,3 c]quinolines
Ghotekar, Bhausaheb Kedarnath,Ghagare, Maruti G.,Toche, Raghunath B.,Jachak, Madhukar N.
experimental part, p. 169 - 175 (2010/08/05)
Synthesis of novel benzo[h]-1,6-naphthyridines was successfully achieved by cyclocondensation of ethyl 4-aminoquinoline-3-carboxylates with malononitrile. The pyrazolo[4,3-c]quinolines were synthesized by nucleophilic substitution and subsequent addition
Synthesis of 4-quinolylazide derivatives and evaluation of their antitumor and antimicrobial activity
Savini,Massarelli,Pellerano
, p. 515 - 528 (2007/10/02)
Synthesis and pharmacological evaluation of a series of 4-quinolylazide derivatives are reported. These were screened against P388 lymphocitic leukemia in mice, but they resulted inactive. All the compounds were also tested for their antimicrobial activity against gram-positive, gram-negative strains and fungi; only three derivatives exhibited poor activity.
Penicillins
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, (2008/06/13)
New penicillin antibiotics are disclosed which are effective antibacterial agents and which belong to the class of α-(heterocyclic acylamino) penicillins and their salts and esters together with pharmaceutical compositions containing the same and their method of administration. The new compounds are characterized by having an amino substituent on the heterocyclic ring which is linked through an acylamino group to the α-carbon atom of the penicillin side chain. Procedure for preparing the new penicillins is described as well as the antibacterial activity of exemplary compounds against typical microorganisms.
