68271-50-1Relevant academic research and scientific papers
One-pot synthesis of trans-β-lactams from ferrocenylketene generated by thermal Wolff rearrangement
Liu, Mingshun,Wang, Jian’an,Yuan, Xiaoxi,Jiang, Rong,Fu, Nanyan
, p. 2369 - 2377 (2017/12/12)
A series of β-lactams containing the ferrocene moiety were synthesized through the Staudinger reaction between ferrocenylketene generated by the thermal Wolff rearrangement of the corresponding diazo ketone and various imines. The stereochemical outcome h
Tris(oxazoline)/copper-catalyzed coupling of alkynes with nitrones: A highly enantioselective access to β-lactams
Chen, Jiang-Hua,Liao, Sai-Hu,Sun, Xiu-Li,Shen, Qi,Tang, Yong
supporting information; experimental part, p. 5042 - 5045 (2012/08/07)
Chiral tris(oxazoline)/Cu(I) complexes are demonstrated as a type of efficient catalysts for the asymmetric Kinugasa reaction of terminal alkynes with C-arylnitrones, providing a highly enantio- and diastereoselective access to optically active β-lactams.
Studies of multicomponent Kinugasa reactions in aqueous media
McKay, Craig S.,Kennedy, David C.,Pezacki, John Paul
supporting information; experimental part, p. 1893 - 1896 (2009/07/05)
Micelle-promoted, copper-catalyzed multicomponent Kinugasa reactions were studied in aqueous media. Reactions were performed in a 'single pot' for a series of in situ generated C,N-diphenylnitrones with Cu(I) phenylacetylide providing β-lactams in yields of 45-85%. Substituents affect the reaction by either accelerating cycloaddition or minimizing side reactions.
Synthesis and antimicrobial activity of 1,3,4-triaryl-2-azetidinones
Diurno,Mazzoni,Piscopo,Bolognese
, p. 239 - 247 (2007/10/02)
A set of substituted 1,3,4-triaryl-2-azetidinones were synthesized and characterized. Their antimicrobial activity, against Gram+ and Gram- bacteria and Fungi, was tested. The compounds 23 and 30 showed remarkable activity against Pseudomonas aeruginosa.
On the azetidin-2-one ring formation. A 1H NMR investigation
Bolognese, Adele,Diurno, M. Vittoria,Mazzoni, Orazio,Giordano, Federico
, p. 7417 - 7428 (2007/10/02)
Azetidin-2-ones were prepared by addition of phenylacetic acid chloride to substituted benzal-anilines in DMF. The effect of temperature and substituents at the benzal-anilines on the reaction mechanism was investigated carrying out the reaction in DMF d7 in an NMR probe of a Bruker 400-MHz spectrometer at 25 and 60°C. Proton signals, arising from two kinds of intermediates a 2-phenyl-N-(α-chlorobenzyl)-acetanilide (6) and a nitrogen-charged adduct (7) suggest that two competitive mechanisms play a role in the formation of trans and cis azetidin-2-ones.
